2.1

2.1.0

Version 2.1.0 of the GA4GH Variation Representation Specification (VRS) adds support for intronic positions, including new classes for relative sequence locations and relative alleles. It also revises the normalization algorithm for ambiguous insertions to select the smallest repeat-unit factor rather than the greatest, changing the normalized (and therefore digested) representation of affected trial-use Allele instances.

Minor Version Increment

• revises the Normalization algorithm for ambiguous insertions to select the smallest repeat-unit factor rather than the greatest, changing the normalized (and therefore digested) representation of affected trial-use Allele instances by @ahwagner in https://github.com/ga4gh/vrs/pull/700

Patch Version Increment

• adds Relative Sequence Location, Sequence Offset Location, and Relative Allele to support intronic positions, all at draft maturity, by @korikuzma in https://github.com/ga4gh/vrs/pull/675

• fixes type and ga4gh.inherent for the draft intronic position classes by @korikuzma in https://github.com/ga4gh/vrs/pull/684

• adds tests for ensuring correct properties by @korikuzma in https://github.com/ga4gh/vrs/pull/686

• adds a Relative Allele example and intronic-position normalization rules by @larrybabb in https://github.com/ga4gh/vrs/pull/689

• fixes inconsistent seed_length formatting in normalization docs by @harshitmishra00182-ops in https://github.com/ga4gh/vrs/pull/702

• bumps the GKS-core submodule from 1.0.0 to 1.1.0 and, later, to 1.2.0-ballot.2026-07; the only classes touched upstream (Mappable Concept, ConceptSet) are not inherited or embedded by any VRS class, so neither bump carries a data-compatibility impact into VRS by @korikuzma and @ahwagner in https://github.com/ga4gh/vrs/pull/664

• removes broken refs in releases by @jsstevenson in https://github.com/ga4gh/vrs/pull/647

• fixes a few warnings, removes anonymous entries from search results by @jsstevenson in https://github.com/ga4gh/vrs/pull/646

• adds ConceptSet and reorders changelog by @korikuzma in https://github.com/ga4gh/vrs/pull/666

• auto-updates copyright year by @jsstevenson in https://github.com/ga4gh/vrs/pull/673

• fixes refs, adds warnings check to CI/CD by @jsstevenson in https://github.com/ga4gh/vrs/pull/671

• fixes orphaned pages showing up in search results by @jsstevenson in https://github.com/ga4gh/vrs/pull/672

• fixes the img.shields.io link for the docs badge by @korikuzma in https://github.com/ga4gh/vrs/pull/685

• adds quick start guidance by @brendanreardon in https://github.com/ga4gh/vrs/pull/693

• minor cosmetic and doc updates by @larrybabb in https://github.com/ga4gh/vrs/pull/698

• adds a citation file by @jsstevenson in https://github.com/ga4gh/vrs/pull/701

• removes an old unused TODO file by @jsstevenson in https://github.com/ga4gh/vrs/pull/703